Scientist, In Vivo Genomics

What You Will Contribute To Altos

We are seeking an exceptional and versatile Scientist to join Discovery Science at Altos Labs. This role is ideal for a creative experimental scientist with deep expertise in functional genomics, in vivo biology, and/or next-generation genomics technologies who is excited to uncover new regulators of cell state, tissue resilience, and rejuvenation biology.

The successful candidate will help build and apply next-generation discovery platforms spanning in vitro and in vivo systems, with opportunities to contribute across areas such as genome-scale perturbation screening, in vivo genomics technology development, target discovery, and tissue-level functional genomics. Depending on background and interests, the successful candidate may contribute more heavily toward platform and technology development or toward mechanistic and translational biology.

We are looking for broadly capable scientists with strong technical depth, scientific creativity, and the curiosity to pursue new biological frontiers in a highly collaborative environment.

Key Responsibilities

• Design and execute innovative research strategies to identify causal regulators of cell state, aging, regeneration, and disease biology.
• Develop and apply functional genomics approaches, including pooled perturbation screens, CRISPR-based technologies, and other scalable discovery tools.
• Build and apply in vivo genomics approaches to enable target discovery and mechanistic studies in physiologically relevant systems.
• Develop robust experimental workflows connecting genetic perturbation to molecular and phenotypic readouts across cellular and animal models.
• Apply genomic and molecular profiling methods, including transcriptome, translatome, proteome, single- cell, and spatial readouts, to uncover novel biological mechanisms.
• Generate mechanistic hypotheses and drive validation studies using appropriate in vitro and in vivo systems.
• Translate in vitro discoveries into in vivo systems through the design and execution of hands-on mouse studies in relevant disease models.
• Develop, optimize, and apply in vivo delivery approaches, including viral and nucleic acid-based delivery systems such as AAV and LNP platforms.
• Collaborate closely with computational scientists and cross-functional teams to integrate multidimensional datasets and generate actionable biological insight.
• Lead project strategy, experimental design, execution, troubleshooting, and data interpretation.
• Contribute to publications, patents, and broader scientific strategy.

Who You Are

• PhD in Molecular Biology, Genetics, Genomics, Biochemistry, Bioengineering, Systems Biology, or related field, with relevant postdoctoral and/or industry experience preferred.
• Strong track record of scientific accomplishment through publications, patents, or impactful platform development.
• Demonstrated expertise in two or more of the following areas:
• Functional genomics, perturbation screening, single-cell, spatial, or other next-generation genomics technologies
• Hands-on in vivo experience with disease mouse models.
• Disease cell and mechanistic biology
• Bioinformatics and multi-omic data analysis
• Ability to independently lead complex research projects from concept to execution.
• Strong analytical skills and ability to derive biological insight from multidimensional datasets.
• Excellent written and verbal communication skills.
• Demonstrated ability to work effectively in highly collaborative, interdisciplinary environments.
• Scientific rigor, creativity, and comfort operating in rapidly evolving areas.

Preferred Qualifications

• Experience with in vivo functional genomics or pooled screening approaches.
• Expertise in single-cell sequencing, spatial genomics, ribosome profiling, lineage tracing, or other next-generation genomics methods.
• Experience in small rodent handling, with an ability to independently design and coordinate the execution of complex in vivo studies, including drug administration, tissue harvest and processing.
• Hands-on experience with in vivo delivery modalities including AAV, LNP, or related delivery systems.
• Expertise in physiologically relevant model systems, including stem cell-derived systems, primary human cells, organoids, ex vivo tissue systems, or disease mouse models.
• Experience linking large-scale discovery platforms to mechanistic follow-up and target validation.
• Strong computational biology and bioinformatics expertise integrating transcriptomic, proteomic, translatomic, imaging, phenotypic screening, and other multi-omic datasets.
• Background in aging biology, regeneration, fibrosis, inflammation, metabolic disease, neurodegeneration, or related therapeutic areas.
• Experience or interest in studying novel biological mechanisms and emerging areas of biology.

The salary range for Redwood City:

• Scientist I, Genomics: $148,700 - $190,700
• Scientist II, Genomics: $162,700 - $208,600
• Senior Scientist I, Genomics: $197,000 - $252,600

Exact compensation may vary based on skills, experience, and location.

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